Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial interim results
May 09, 2022
Nature Medicine
Changsong Qi, Jifang Gong, Jian Li, Dan Liu, Yanru Qin, Sai Ge, Miao Zhang, Zhi Peng, Jun Zhou, Yanshuo Cao, Xiaotian Zhang, Zhihao Lu, Ming Lu, Jiajia Yuan, Zhenghang Wang, Yakun Wang, Xiaohui Peng, Huiping Gao, Zhen Liu, Huamao Wang, Daijing Yuan, Jun Xiao, Hong Ma, Wei Wang, Zonghai Li & Lin Shen
Chimeric anti-GPC3 sFv-CD3ε receptor-modified T cells with IL7 co-expression for the treatment of solid tumors
Apr 19, 2022
Molecular Therapy Oncolytics
Yansha Sun, Yiwei Dong, Ruixin Sun, Yifan Liu, Yi Wang, Hong Luo, Bizhi Shi, Hua Jiang, Zonghai Li
Coexpression of IL7 and CCL21 Increases Efficacy of CAR-T Cells in Solid Tumors without Requiring Preconditioned Lymphodepletion
Oct 01, 2020
CLINICAL CANCER RESEARCH
Hong Luo, Jingwen Su, Ruixin Sun, Yansha Sun, Yi Wang, Yiwei Dong, Bizhi Shi, Hua Jiang, and Zonghai Li
Olaparib Suppresses MDSC Recruitment via SDF1a/CXCR4 Axis to Improve the Anti-tumor Efficacy of CAR-T Cells on Breast Cancer in Mice
Sep 26, 2020
Molecular Therapy
Ruixin Sun, Hong Luo, Jingwen Su, Shengmeng Di, Min Zhou, Bizhi Shi, Yansha Sun, Guoxiu Du, Honghong Zhang, Hua Jiang, and Zonghai Li
Chimeric Antigen Receptor-Glypican-3 T-Cell Therapy for Advanced Hepatocellular Carcinoma: Results of Phase I Trials
Aug 01, 2020
CLINICAL CANCER RESEARCH
Donghua Shi, Yaoping Shi, Ahmed O. Kaseb, Xingxing Qi, Yuan Zhang, Jiachang Chi, Qing Lu, Huiping Gao, Hua Jiang, HuamaoWang, Daijing Yuan, HongMa, HongyangWang, Zonghai Li, and Bo Zhai
LRCH1 deficiency enhances LAT signalosome formation and CD8+ T cell responses against tumors and pathogens
Jan 21, 2020
PNAS
Chang Liua, Xiaoyan Xu, Lei Han, Xiaopeng Wan, Lingming Zheng, Chunyang Li, Zhaohui Liao, Jun Xiao, Ruiyue Zhong, Xin Zheng, Qiong Wang, Zonghai Li, Hualan Chene, Bin Wei, and Hongyan Wang
Target-Dependent Expression of IL12 by synNotch Receptor-Engineered NK92 Cells Increases the Antitumor Activities of CAR-T Cells
Dec 19, 2019
Frontiers in Oncology
Hong Luo, Xiuqi Wu, Ruixin Sun, Jingwen Su, Yi Wang, Yiwei Dong, Bizhi Shi , Yansha Sun, Hua Jiang and Zonghai Li
Genetically engineered T cells for cancer immunotherapy
Sep 20, 2019
Signal Transduction and Targeted Therapy
Dan Li, Xue Li, Wei-Lin Zhou, Yong Huang, Xiao Liang, Lin Jiang, Xiao Yang, Jie Sun, Zonghai Li, Wei-Dong Han and Wei Wang
Armored Inducible Expression of IL-12 Enhances Antitumor Activity of Glypican-3–Targeted Chimeric Antigen Receptor–Engineered T Cells in Hepatocellular Carcinoma
Jul 01, 2019
The Journal of Immunology
Ying Liu, Shengmeng Di, Bizhi Shi, Honghong Zhang, Yi Wang, Xiuqi Wu, Hong Luo, Huamao Wang, Zonghai Li, and Hua Jiang
Combined Antitumor Effects of Sorafenib and GPC3-CAR T Cells in Mouse Models of Hepatocellular Carcinoma
Apr 29, 2019
Molecular Therapy
Xiuqi Wu, Hong Luo, Bizhi Shi, Shengmeng Di, Ruixin Sun, Jingwen Su, Ying Liu, Hua Li, Hua Jiang, and Zonghai Li